Ilja Arts

Professor

Ilja Arts is Professor of Molecular Epidemiology of Chronic Diseases at the Dept. of Epidemiology, Principal Investigator at CARIM, and founding Scientific Director of the Maastricht Centre for Systems Biology (MaCSBio; www.maastrichtuniversity.nl/macsbio) at Maastricht University. She leads the research line on Systems Medicine of Chronic Diseases, which aims to elucidate biological mechanisms that play a role in the development and prognosis of cardiometabolic diseases such as obesity, type 2 diabetes and cardiovascular disease. The research generates novel biomarkers, new leads for prevention and treatment, and improved risk stratification, thus enabling a biology-based approach to personalised health. It involves the integration of large, multi-dimensional data (genomics, transcriptomics, metabolomics, microbiome, clinical, lifestyle) from deep-phenotyped cohorts with genome scale metabolic and dynamical models, and pathway and network models.

Prof. Arts obtained a PhD in Human Nutrition (Wageningen, 2001), a MSc in Epidemiology (Rotterdam, 2000), and a MSc in Human Nutrition and Health (cum laude; Wageningen 1994). In 2004 she received a Veni grant from the Netherlands Organisation for Scientific Research (NWO). Prof. Arts has generated over 5.7 M€ competitive funding as applicant or co-applicant. Funders include NWO, ZonMW, Public Private Partnerships (e.g. Top Institute Food and Nutrition, Carbohydrate Competence Centre), EU Horizon 2020, and Province of Limburg. She is an experienced supervisor of PhD candidates and has published over 88 peer reviewed scientific papers in international journals. She has extensive experience in developing, coordinating, and teaching courses in a variety of topics at the Bachelor, Master, and post-doctoral level and has initiated and developed courses in innovative topics such as molecular epidemiology that are now part of the standard curricula.

Prof. Arts is a member of the board of the Netherlands Bioinformatics & Systems Biology research school BioSB, member of the Scientific Advisory Committee of the Dutch Techcentre for Life Sciences (DTL), and is a board member for the NWO Domain Science (ENW).

Maastricht Centre for Systems Biology MaCSBio
Universiteitssingel 60, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2020
    • Lenz, M., Arts, I. C. W., Peeters, R. L. M., de Kok, T. M., & Ertaylan, G. (2020). Adipose tissue in health and disease through the lens of its building blocks. Scientific Reports, 10(1), [10433]. https://doi.org/10.1038/s41598-020-67177-1
    • DiOGenes Consortium (2020). Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study. International Journal of Obesity, 44(6), 1376-1386. https://doi.org/10.1038/s41366-020-0565-z
    • BBMRI-NL Metabolomics Consortium (2020). Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls. Biological Psychiatry, 87(5), 409-418. https://doi.org/10.1016/j.biopsych.2019.08.016
    • Sarathy, C., Kutmon, M., Lenz, M., Adriaens, M. E., Evelo, C. T., & Arts, I. C. W. (2020). EFMviz: A COBRA Toolbox extension to visualize Elementary Flux Modes in Genome-Scale Metabolic Models. Metabolites, 10(2), [66]. https://doi.org/10.3390/metabo10020066
    • Tareen, S. H. K., Kutmon, M., de Kok, T. M., Mariman, E. C. M., van Baak, M. A., Evelo, C. T., Adriaens, M. E., & Arts, I. C. W. (2020). Stratifying cellular metabolism during weight loss: an interplay of metabolism, metabolic flexibility and inflammation. Scientific Reports, 10(1), [1651]. https://doi.org/10.1038/s41598-020-58358-z
    • Josefs, T., Wouters, K., Tietge, U. J. F., Annema, W., Dullaart, R. P. F., Vaisar, T., Arts, I. C. W., van der Kallen, C. J. H., Stehouwer, C. D. A., Schalkwijk, C. G., Goldberg, I. J., Fisher, E. A., & van Greevenbroek, M. M. J. (2020). High-density lipoprotein cholesterol efflux capacity is not associated with atherosclerosis and prevalence of cardiovascular outcome: The CODAM study. Journal of Clinical Lipidology, 14(1), 122-132.e4. https://doi.org/10.1016/j.jacl.2019.10.012
  • 2019
    • van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T., & Blaak, E. E. (2019). Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans. Diabetes, 68(12), 2247-2258. https://doi.org/10.2337/db19-0560
    • O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A., & Arts, I. C. W. (2019). A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data. PLoS Computational Biology, 15(10), [e1007400]. https://doi.org/10.1371/journal.pcbi.1007400
    • Tareen, S. H., Kutmon, M., Arts, I. C., de Kok, T. M., Evelo, C. T., & Adriaens, M. E. (2019). Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level. Genes and nutrition, 14(1), [27]. https://doi.org/10.1186/s12263-019-0647-5
    • Ahluwalia, T. S., Tofte, N., Vogelzangs, N., Mook-Kanamori, D., Brahimaj, A., Frimodt-Moller, M., Arts, I., Beulens, J., van der Heijden, A., Stehouwer, C., Nijpels, G., van Greevenbroek, M., van der Kallen, C., Rossing, P., & 't Hart, L. M. (2019). Plasma metabolomics identifies markers of kidney function in 3,064 Europeans with type 2 diabetes. Diabetologia, 62, S456-S456.