Henri Spronk

Associate professor

Initially trained in Biochemistry and Molecular Biology at Nijmegen University, Dr Henri Spronk obtained a PhD in Biochemistry on the effects of impaired vitamin K-dependent protein carboxylation.

The focus of his current work is on the bidirectional relation between coagulation and inflammation, as well as on the applicability of functional plasma assays such as thrombin generation, for atherothrombotic risk prediction. He has a special interest in the role of active coagulation factors, mainly thrombin, in activation of protein-activated receptors (PARs) which can regulate the balance between vascular protective and disruptive. Overall, knowledge on the non-haemostatic functions of thrombin and factor Xa enables pharmacological interference in cellular processes contributing to the the development and progression of atherosclerosis or atrial fibrillation.

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.326
T: +31(0)43 388 42 61

  • 2024
    • Ceulemans, A., Spronk, H. M. H., Ten Cate, H., van Zwam, W. H., van Oostenbrugge, R. J., & Nagy, M. (2024). Current and potentially novel antithrombotic treatment in acute ischemic stroke. Thrombosis Research, 236, 74-84. https://doi.org/10.1016/j.thromres.2024.02.009
    • Busch, M. H., Ysermans, R., Aendekerk, J., Timmermans, S. A., Potjewijd, J., Damoiseaux, J., Spronk, H. M. H., Ten Cate, H., Reutelingsperger, C., Nagy, M., & van Paassen, P. (2024). The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-Associated Vasculitis. Blood advances, 8(5), 1295-1304. https://doi.org/10.1182/bloodadvances.2023011937
    • Reutelingsperger, C. P. M., Gijbels, M. J., Spronk, H., Van Oerle, R., Schrijver, R., Ekhart, P., de Kimpe, S., & Nicolaes, G. A. F. (2024). M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation. International Journal of Molecular Sciences, 25(3), Article 1376. https://doi.org/10.3390/ijms25031376
    • Baaten, C. C. F. M. J., Nagy, M., Bergmeier, W., Spronk, H. M. H., & van der Meijden, P. E. J. (2024). Platelet biology and function: plaque erosion vs. rupture. European Heart Journal, 45(1), 18-31. https://doi.org/10.1093/eurheartj/ehad720
  • 2023
    • Mulder, M. M. G., Schellens, J., Sels, J.-W. E. M., van Rosmalen, F., Hulshof, A.-M., de Vries, F., Segers, R., Mihl, C., van Mook, W. N. K. A., Bast, A., Spronk, H. M. H., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Schurgers, L. J., Drent, M., & van Bussel, B. C. T. (2023). Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort. Journal of Intensive Care, 11(1), Article 63. https://doi.org/10.1186/s40560-023-00712-0
    • Jacobs, L. M. C., Wintjens, M. S. J. N., Nagy, M., Willems, L., ten Cate, H., Spronk, H. M. H., van Kuijk, S. M. J., Ghossein-Doha, C., Netea, M. G., Groh, L. A., van Petersen, A. S., & Warle, M. C. (2023). Biomarkers of sustained systemic inflammation and microvascular dysfunction associated with post-COVID-19 condition symptoms at 24 months after SARS-CoV-2-infection. Frontiers in Immunology, 14(1), Article 1182182. https://doi.org/10.3389/fimmu.2023.1182182
    • Baidildinova, G., Pallares Robles, A., ten Cate, V., Kremers, B. M. M., Heitmeier, S., ten Cate, H., Mees, B. M. E., Spronk, H. M. H., Wild, P. S., ten Cate-Hoek, A. J., & Jurk, K. (2023). Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease. Thrombosis Research, 230(1), 105-118. https://doi.org/10.1016/j.thromres.2023.08.017
    • Alnima, T., Meijer, R. I., Spronk, H. M. H., Warlé, M., & Cate, H. T. (2023). Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease. Cardiovascular Diabetology, 22(1), Article 257. https://doi.org/10.1186/s12933-023-01990-6
    • Musgrave, K. M., Scott, J., Sendama, W., Gardner, A. I., Dewar, F., Lake, C. J., Spronk, H. M. H., van Oerle, R., Visser, M., ten Cate, H., Kesteven, P., Fuller, A., McDonald, D., Knill, C., Hulme, G., Filby, A., Wright, S. E., Roy, A. I., Ruchaud-Sparagano, M.-H., ... Rostron, A. J. (2023). Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis. Thrombosis Research, 228(1), 10-20. https://doi.org/10.1016/j.thromres.2023.05.018
    • Nagy, M., Robles, A. P., Visser, M., Koeck, T., ten Cate, V., ten Cate-Hoek, A. J., Schwers, S., Heitmeier, S., ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2023). Predictive value for increased activated factor XI activity in acute venous thromboembolism. Journal of Thrombosis and Haemostasis, 21(6), 1610-1622. https://doi.org/10.1016/j.jtha.2023.02.031