Frits Prinzen


Frits Prinzen is professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 280 scientific articles, with 7740 citations and H-index of 50.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2020
    • Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530.
    • Lumens, J., Willemen, E., & Prinzen, F. W. (2020). Does the Right Go Wrong During Cardiac Resynchronization Therapy?JACC-Cardiovascular Imaging, 13(7), 1485-1488.
    • Kloosterman, M., van Stipdonk, A. M. W., ter Horst, I., Rienstra, M., Van Gelder, I. C., Vos, M. A., Prinzen, F. W., Meine, M., Vernooy, K., & Maass, A. H. (2020). Association between heart failure aetiology and magnitude of echocardiographic remodelling and outcome of cardiac resynchronization therapy. Esc heart failure, 7(2), 645-653.
    • van Stipdonk, A. M. W., Hoogland, R., Ter Horst, I., Kloosterman, M., Vanbelle, S., Crijns, H. J. G. M., Prinzen, F. W., Meine, M., Maass, A. H., & Vernooy, K. (2020). Evaluating Electrocardiography-Based Identification of Cardiac Resynchronization Therapy Responders Beyond Current Left Bundle Branch Block Definitions. JACC: Clinical Electrophysiology, 6(2), 193-203.
    • Jurak, P., Curila, K., Leinveber, P., Prinzen, F. W., Viscor, I., Plesinger, F., Smisek, R., Prochazkova, R., Osmancik, P., & Halamek, J. (2020). Novel ultra-high-frequency electrocardiogram tool for the description of the ventricular depolarization pattern before and during cardiac resynchronization. Journal of Cardiovascular Electrophysiology, 31(1), 300-307.
  • 2019
    • Lee, A. W. C., Nguyen, U. C., Razeghi, O., Gould, J., Sidhu, B. S., Sieniewicz, B., Behar, J., Mafi-Rad, M., Plank, G., Prinzen, F. W., Rinaldi, C. A., Vernooy, K., & Niederer, S. (2019). A rule-based method for predicting the electrical activation of the heart with cardiac resynchronization therapy from non-invasive clinical data. Medical Image Analysis, 57, 197-213.
    • Zweerink, A., Salden, O. A. E., van Everdingen, W. M., de Roest, G. J., van de Ven, P. M., Cramer, M. J., Doevendans, P. A., van Rossum, A. C., Vernooy, K., Prinzen, F. W., Meine, M., & Allaart, C. P. (2019). Hemodynamic Optimization in Cardiac Resynchronization Therapy: Should We Aim for dP/dtmax or Stroke Work?JACC: Clinical Electrophysiology, 5(9), 1013-1025.
    • Fixsen, L. S., de Lepper, A. G. W., Strik, M., van Middendorp, L. B., Prinzen, F. W., van de Vosse, F. N., Houthuizen, P., & Lopata, R. G. P. (2019). ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT BUNDLE BRANCH-RELATED STRAIN DYSSYNCHRONY: A COMPARISON WITH TAGGED MRI. Ultrasound in Medicine and Biology, 45(8), 2063-2074.
    • Zhou, Q., Zeng, Y., Xiong, Q., Zhong, S., Li, P., Ran, H., Yin, Y., Reutelingsperger, C., Prinze, F. W., & Ling, Z. (2019). Construction of CNA35 Collagen-Targeted Phase-Changeable Nanoagents for Low-Intensity Focused Ultrasound-Triggered Ultrasound Molecular Imaging of Myocardial Fibrosis in Rabbits. ACS Applied Materials & Interfaces, 11(26), 23006-23017.
    • van Stipdonk, A. M. W., Vanbelle, S., ter Horst, I. A. H., Luermans, J. G., Meine, M., Maass, A. H., Auricchio, A., Prinzen, F. W., & Vernooy, K. (2019). Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy. International Journal of Cardiology, 286, 61-65.