Emiel van der Vorst

Post doc

Dr Emiel van der Vorst studied Cardiovascular Biology and Medicine at Maastricht University. After an internship in Sydney, Australia in the lab of Prof. Rye and Prof. Barter, he graduated in 2010. In 2015, he obtained his PhD, under the supervision of Prof. Biessen, Prof. De Winther and Dr Donners at the Department of Pathology, CARIM, Maastricht. The title of his thesis was: 'Modulation of vascular inflammation – cell-type specific effects of ADAMs and HDL'.

During his post-doctoral period (2015-2019) at the Institute for Cardiovascular Prevention in the lab of Prof. Weber and Dr Döring, he obtained several personal grants (Humboldt Foundation, FöFoLe, DZHK) to start establishing his own research line. In 2019, he obtained several prestigious personal grants (Veni, IZKF research group grant, Else-Kröner Fresenius), enabling him to start his own group at CARIM and IMCAR (Aachen, Germany). As principle investigator of the Immune-Lipid Crosstalk Research Group, he currently supervises 1 post-doctoral fellow and 3 PhD students.

Dr Van der Vorst focusses on the interplay between lipids and the immune-system in the context of cardiovascular disease (CVD). Recently, evidence is mounting, including from his own research that main driving factors of CVD, dyslipidemia and inflammation, are interdependent and that considerable crosstalk exists between these two. Combining his expertise on high-density lipoproteins (HDL) and chemokine receptors, he will investigate the interplay between these two factors. In addition, the interplay of various other lipids and lipid derivatives with key immunological factors will be investigated, hopefully elucidating new therapeutic targets.

Special interest of his research group also goes to a so far fairly neglected subgroup of patients in respect to cardiovascular risk, being chronic kidney disease (CKD) patients. It has been clearly shown that CKD patients have a severely increased incidence of CVD, clearly demonstrated by the fact that almost half of the CKD patients die from CVD rather than from the primary kidney disease. Intriguingly, this increased CVD risk in CKD patients cannot be fully explained by the classical CVD risk factors like hypertension or dyslipidemia, suggesting the existence of CKD-specific cardiovascular risk factors. The aim is therefore to explore the role of immune-lipid crosstalk as pathological mechanism in CKD that could contribute to this increased CVD-risk.

Department of Pathology
P. Debeyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht

  • 2022
    • Wollenhaupt, J., Frisch, J., Harlacher, E., Wong, D. W. L., Jin, H., Schulte, C., Vondenhoff, S., Moellmann, J., Klinkhammer, B. M., Zhang, L., Baleanu-Curaj, A., Liehn, E. A., Speer, T., Kazakov, A., Werner, C., van der Vorst, E. P. C., Selejan, S-R., Hohl, M., Böhm, M., ... Noels, H. (2022). Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease. Redox Biology, 56, [102459]. https://doi.org/10.1016/j.redox.2022.102459
    • Ganesh, N., van der Vorst, E. P. C., Spiesshöfer, J., He, S., Burgmaier, M., Findeisen, H., Lehrke, M., Swirski, F. K., Marx, N., & Kahles, F. (2022). Gut immune cells-A novel therapeutical target for cardiovascular disease?Frontiers in cardiovascular medicine, 9, [943214]. https://doi.org/10.3389/fcvm.2022.943214
    • Jin, H., Maas, S. L., Lu, C., Nagenborg, J., Manca, M., Karel, J. M. H., Cavill, R., Waring, O., Sikkink, C. J. J. M., Mees, B. M. E., Daemen, M. J. A. P., Smirnov, E., Sluimer, J., Van der Vorst, E., & Biessen, E. A. L. (2022). Identification Of Cd8+T Cell Prdm1 In High-Risk Human Plaques And Its Regulatory Role In Murine Lesion Development. Atherosclerosis, 355, E9-E9.
    • Maas, S. L., Jin, H., Lu, C., Nagenborg, J., Manca, M., Karel, J. M. H., Cavill, R., Waring, O., Sikkink, C. J. J. M., Mees, B. M. E., Daemen, M. J. A. P., Smirnov, E., Sluimer, J., van der Vorst, E. P. C., & Biessen, E. A. L. (2022). Identification of CD8+T cell PRDM1 in high-risk human plaques and its regulatory role in murine lesion development. Cardiovascular Research, 118(SUPPL 1). https://doi.org/10.1093/cvr/cvac066.186
    • Gencer, S., Döring, Y., Jansen, Y., Bayasgalan, S., Yan, Y., Bianchini, M., Cimen, I., Müller, M., Peters, L. J. F., Megens, R. T. A., von Hundelshausen, P., Duchene, J., Lemnitzer, P., Soehnlein, O., Weber, C., & van der Vorst, E. P. C. (2022). Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Basic Research in Cardiology, 117(1), 17. [30]. https://doi.org/10.1007/s00395-022-00937-4
    • Liu, Y., Shi, J. Z., Jiang, R., Liu, S. F., He, Y. Y., van der Vorst, E. P. C., Weber, C., Doering, Y., & Yan, Y. (2022). Regulatory T Cell-Related Gene Indicators in Pulmonary Hypertension. Frontiers in Pharmacology, 13, [908783]. https://doi.org/10.3389/fphar.2022.908783
    • Evans, B. R., Yerly, A., van der Vorst, E. P. C., Baumgartner, I., Bernhard, S. M., Schindewolf, M., & Döring, Y. (2022). Inflammatory Mediators in Atherosclerotic Vascular Remodeling. Frontiers in cardiovascular medicine, 9, [868934]. https://doi.org/10.3389/fcvm.2022.868934
    • Peters, L. J. F., Baaten, C. C. F. M. J., Maas, S. L., Lu, C., Nagy, M., Jooss, N. J., Bidzhekov, K., Santovito, D., Moreno-Andrés, D., Jankowski, J., Biessen, E. A. L., Döring, Y., Heemskerk, J. W. M., Weber, C., Kuijpers, M. J. E., & van der Vorst, E. P. C. (2022). MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines, 10(5), [983]. https://doi.org/10.3390/biomedicines10050983
    • Van der Vorst, E. P. C., & Biessen, E. A. L. (2022). Unwrapped and uNCORked: PPAR-γ repression in atherosclerosis. European Heart Journal, 43(7), E32-E34. [ehz770]. https://doi.org/10.1093/eurheartj/ehz770
    • Haghikia, A., Zimmermann, F., Schumann, P., Jasina, A., Roessler, J., Schmidt, D., Heinze, P., Kaisler, J., Nageswaran, V., Aigner, A., Ceglarek, U., Cineus, R., Hegazy, A. N., van der Vorst, E. P. C., Döring, Y., Strauch, C. M., Nemet, I., Tremaroli, V., Dwibedi, C., ... Landmesser, U. (2022). Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism. European Heart Journal, 43(6), 518–533. https://doi.org/10.1093/eurheartj/ehab644