Christian Weber

Professor

Prof. Christian Weber is the Chair in Vascular Medicine and the Director of the Institute for Cardiovascular Prevention at Ludwig-Maximilians-University (LMU) Munich, Germany, and Professor at the CARIM. After graduating and completing his training in internal medicine at LMU and Harvard Medical School, Boston, he was board-certified in clinical cardiology and appointed as a Chair in Molecular Cardiology at RWTH Aachen University. His group has a strong interest in the molecular interactions and patho-physiological functions of chemokines and immune cell subsets, as well as the role of microRNAs and their targets in vascular disease and atherosclerosis, while his clinical interests focus on developing novel biomarkers and biopharmaceuticals. He is the Spokesman of the DFG Collaborative Research Centre SFB1123 and coordinates the partner site Munich Heart Alliance in the German Centre for Cardiovascular Research (DZHK). Among numerous awards, he is a double ERC Advanced Investigator Grant recipient and Clarivate Analytics Highly Cited Researcher with more than 560 publications and an h-index of 97. He serves as the Editor-in-Chiefof Thrombosis&Haemostasis, Senior Associate Editor of Arteriosclerosis, Thrombosis & Vascular Biology andco-founderofCarolusTherapeutics Inc. and Cartesio Therapeutics Inc.

  • Vascular Immunotherapy, German Centre for Cardiovascular Research (BMBF DZHK
  • MHA VD1.2), 2019-2020
  • Munich Cluster for Systems Neurology (SyNergy), DFG Excellence Initiative, 2019-2026
  • ERC Advanced Grant °692511, PROVASC: Cell-specific vascular protection by CXCL12/CXCR4, 2016- 2022 ERC AdG
  • NIH 1R01HL122843, Molecular mechanisms linking CXCL12 to atherosclerosis, 2017-2020
  • DFG Collaborative Research Centre 1123 Atherosclerosis: new therapeutic targets, 2014-2022

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2024
    • Döring, Y., van der Vorst, E. P. C., Yan, Y., Neideck, C., Blanchet, X., Jansen, Y., Kemmerich, M., Bayasgalan, S., Peters, L. J. F., Hristov, M., Bidzhekov, K., Yin, C., Zhang, X., Leberzammer, J., Li, Y., Park, I., Kral, M., Nitz, K., Parma, L., ... Weber, C. (2024). Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis. Nature cardiovascular research, 3(2), 221-242. https://doi.org/10.1038/s44161-023-00413-9
    • Lip, G. Y. H., Rigby, A., & Weber, C. (2024). A Happy New Year 2024 from Thrombosis and Haemostasis!Thrombosis and Haemostasis, 124(1), 1-3. https://doi.org/10.1055/s-0043-1778033
    • Weber, C., Rigby, A., & Lip, G. Y. H. (2024). Thrombosis and Haemostasis 2023 Editors' Choice Papers. Thrombosis and Haemostasis, 124(1), 80-87. https://doi.org/10.1055/s-0043-1778032
  • 2023
    • Kral, M., van der Vorst, E. P. C., Surnov, A., Weber, C., & Doering, Y. (2023). ILC2-mediated immune crosstalk in chronic (vascular) inflammation. Frontiers in Immunology, 14, Article 1326440. https://doi.org/10.3389/fimmu.2023.1326440
    • Cimen, I., Natarelli, L., Abedi Kichi, Z., Henderson, J. M., Farina, F. M., Briem, E., Aslani, M., Megens, R. T. A., Jansen, Y., Mann-Fallenbuchel, E., Gencer, S., Duchêne, J., Nazari-Jahantigh, M., van der Vorst, E. P. C., Enard, W., Döring, Y., Schober, A., Santovito, D., & Weber, C. (2023). Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Science translational medicine, 15(720), Article eadf3357. https://doi.org/10.1126/scitranslmed.adf3357
    • Bianchini, M., Moeller-Ramon, Z., Weber, C., Megens, R., & Duchene, J. (2023). Short-term western diet causes rapid and lasting alterations of bone marrow physiology. Thrombosis and Haemostasis, 123(11), 1100-1104. https://doi.org/10.1055/a-2149-4431
    • Pekayvaz, K., Gold, C., Hoseinpour, P., Engel, A., Martinez-Navarro, A., Eivers, L., Coletti, R., Joppich, M., Dionísio, F., Kaiser, R., Tomas, L., Janjic, A., Knott, M., Mehari, F., Polewka, V., Kirschner, M., Boda, A., Nicolai, L., Schulz, H., ... Stark, K. (2023). Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity, 56(10), 2325-2341.e15. https://doi.org/10.1016/j.immuni.2023.08.002
    • Wagner, J. U. G., Tombor, L. S., Malacarne, P. F., Kettenhausen, L. M., Panthel, J., Kujundzic, H., Manickam, N., Schmitz, K., Cipca, M., Stilz, K. A., Fischer, A., Muhly-Reinholz, M., Abplanalp, W. T., John, D., Mohanta, S. K., Weber, C., Habenicht, A. J. R., Buchmann, G. K., Angendohr, S., ... Dimmeler, S. (2023). Aging impairs the neurovascular interface in the heart. Science, 381(6660), 897-906. https://doi.org/10.1126/science.ade4961
    • Sachs, S., Götz, A., Finan, B., Feuchtinger, A., DiMarchi, R. D., Döring, Y., Weber, C., Tschöp, M. H., Müller, T. D., & Hofmann, S. M. (2023). GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovascular Diabetology, 22(1), Article 217. https://doi.org/10.1186/s12933-023-01940-2
    • Weber, C., Habenicht, A. J. R., & von Hundelshausen, P. (2023). Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond. European Heart Journal, 44(29), 2672-2681. https://doi.org/10.1093/eurheartj/ehad304