Chris Reutelingsperger


Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2022
    • Busch, M. H., Timmermans, S. A. M. E. G., Aendekerk, J. P., Ysermans, R., Amiral, J., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., & Paassen, P. V. (2022). Annexin A1 Is Associated with Adverse Clinical Outcomes in Patients with COVID-19. Journal of Clinical Medicine, 11(24), [7486].
    • Fronza Broering, M., Leão, M. C., da Rocha, G. H. O., Scharf, P. R. S., Fillipi Xavier, L., de Cristo Soares Alves, A., Castro, I., Reutelingsperger, C., Klimuk Uchiyama, M., Araki, K., Guterres, S. S., Pohlmann, A. R., & Farsky, S. H. P. (2022). Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis. European Journal of Pharmaceutics and Biopharmaceutics, 181, 49-59.
    • Pavlic, A., Bahram Sangani, N., Kerins, J., Nicolaes, G., Schurgers, L., & Reutelingsperger, C. (2022). Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. International journal of molecular sciences, 23(16), [9178].
    • Oggero, S., Godec, T., van Gorp, R., Pinto, L. A., Schurgers, J. L., Reutelingsperger, C., Sever, P., Norling, L. V., Perretti, M., & Gupta, A. (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Journal of Hypertension, 40(8), 1522-1529.
    • Klein, L., Ophelders, D. R. M. G., van den Hove, D., Damoiseaux, M., Rutten, B. P. F., Reutelingsperger, C. P. M., Schurgers, L. J., & Wolfs, T. G. A. M. (2022). Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis. Brain, Behavior, & Immunity - Health, 23, [100458].
    • Petsophonsakul, P., Burgmaier, M., Willems, B., Heeneman, S., Stadler, N., Gremse, F., Reith, S., Burgmaier, K., Kahles, F., Marx, N., Natour, E., Bidar, E., Jacobs, M., Mees, B., Reutelingsperger, C., Furmanik, M., & Schurgers, L. (2022). Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells. Cardiovascular Research, 118(9), 2196-2210.
    • Jaminon, A. M. G., Rapp, N., Akbulut, A. C., Dzhanaev, R., Reutelingsperger, C. P., Jahnen-Dechent, W., & Schurgers, L. J. (2022). A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro. Journal of visualized experiment, (184), [e64029].
    • van Kuijk, K., Demandt, J. A. F., Perales-Patón, J., Theelen, T. L., Kuppe, C., Marsch, E., de Bruijn, J., Jin, H., Gijbels, M. J., Matic, L., Mees, B. M. E., Reutelingsperger, C. P. M., Hedin, U., Biessen, E. A. L., Carmeliet, P., Baker, A. H., Kramann, R. K., Schurgers, L. J., Saez-Rodriguez, J., & Sluimer, J. C. (2022). Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling. Cardiovascular Research, 118(5), 1232-1246.
    • You, W., Berendschot, T. T. J. M., Knoops, K., van Zandvoort, M. A. M. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2022). Single Cell Analysis of Reversibility of the Cell Death Program in Ethanol-Treated Neuronal PC12 Cells. International journal of molecular sciences, 23(5), [2650].
    • Hrdinova, J., Fernández, D. I., Ercig, B., Tullemans, B. M. E., Suylen, D. P. L., Agten, S. M., Jurk, K., Hackeng, T. M., Vanhoorelbeke, K., Voorberg, J., Reutelingsperger, C. P. M., Wichapong, K., Heemskerk, J. W. M., & Nicolaes, G. A. F. (2022). Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear. International journal of molecular sciences, 23(4), [2046].