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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Boy Houben

Associate professor

Alfons (Boy) Houben is Associate Professor at the Department of Internal Medicine of Maastricht UMC+. He graduated in Biology at the University of Nijmegen, and received his PhD, in Maastricht in 1993, on early microcirculatory changes in patients with type 1 diabetes. He has longstanding expertise in human (non-invasive) micro- and macrovascular function tests in combination with (pharmacological) interventions, and in the epidemiological setting (The Maastricht Study). Using this unique approach, his main research interest is on the role of microvascular dysfunction in cardiometabolic diseases. An additional focus in his present research is the effects of lifestyle modifications in order to improve microvascular function. He is Past-President of the European Society for Microcirculation, chair of the Dutch Society for Microcirculation and Vascular Biology, and member of several other international scientific societies.

The focus of my research for many years has been microvascular dysfunction (MVD) as both a cause and a consequence of (cardio)metabolic diseases. One important function of the microcirculation is to deliver oxygen/nutrients to all tissues and to remove waste products. In normal metabolism this includes the delivery of glucose, which taken up by the gut following a meal, to skeletal muscle in order to be stored as glycogen. For that, insulin plays an important role by stimulating the endothelium to produce nitric oxide (NO), which leads to recruitment of capillaries in skeletal muscle and thus an increase in exchange surface. As a result, both glucose and insulin can reach skeletal muscle cells quickly and easily in order to store glucose in the cells. In our working hypothesis, we state that MVD may disturb this insulin-mediated glucose delivery/uptake, leading to metabolic insulin resistance and contributing to the development of type 2 diabetes. Within the framework of The Maastricht Study (a population-based cohort study), we perform deep phenotyping of the microcirculation. By using this approach, we are looking for (early) determinants of MVD, and study the role of MVD in the development and progression of various diseases (e.g. (pre)diabetes, heart failure, and depression).

Boy-houben

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht

  • 2025
    • van Oeteren, M. A. J., De Groot, D. M., Buziau, A. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Kroon, A. A., Eussen, S. J. P. M., Dagnelie, P. C., Van Greevenbroek, M. M. J., Houben, A. J. H. M., Meex, S. J. R., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). The effects of dietary fructose on blood pressure are modified by the food matrix. Clinical Nutrition, 55, 134-140. https://doi.org/10.1016/j.clnu.2025.10.017
    • Ahmadi, A., Gorji, H., Shashikant, S., Katz, R., Houben, A. J. H. M., Weinreb, R. N., Allison, M., Meuer, S. M., Klein, B. E., Cotch, M. F., Gutierrez, O. M., Sarnak, M. J., Shlipak, M., Ix, J. H., & Malhotra, R. (2025). Associations of Biomarkers of Kidney Tubule Health with Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis (MESA). Kidney360, 6(12), 2157-2165. https://doi.org/10.34067/KID.0000000970
    • Betz, M. W., Monsegue, A. P., Houben, L. H. P., Hendriks, F. K., van Kranenburg, J., Aussieker, T., Adriaans, B. P., Houben, A. J. H. M., Verdijk, L. B., van Loon, L. J. C., & Snijders, T. (2025). Correction to: Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults (Apr, 10.1007/s40279-025-02229-y, 2025). Sports Medicine, 55(11), 2943-2944. https://doi.org/10.1007/s40279-025-02302-6
    • Ren, Z., Wesselius, A., Kooi, M. E., van Greevenbroek, M., Dagnelie, P., Berendschot, T. T. J. M., Kroon, A. A., Houben, A. J. H. M., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2025). Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study. Diabetologia, 68(10), 2217-2226. https://doi.org/10.1007/s00125-025-06479-3
    • Betz, M. W., Fuchs, C. J., Chedd, F., Monsegue, A. P., Hendriks, F. K., van Kranenburg, J. M. X., Goessens, J., Houben, A. J. H. M., Verdijk, L. B., van Loon, L. J. C., & Snijders, T. (2025). Post-Exercise Cooling Lowers Skeletal Muscle Microvascular Perfusion and Blunts Amino Acid Incorporation into Muscle Tissue in Active Young Adults. Medicine and Science in Sports and Exercise, 57(9), 1866-1876. https://doi.org/10.1249/MSS.0000000000003723
    • Betz, M. W., Monsegue, A. P., Houben, L. H. P., Hendriks, F. K., van Kranenburg, J., Aussieker, T., Adriaans, B. P., Houben, A. J. H. M., Verdijk, L. B., van Loon, L. J. C., & Snijders, T. (2025). Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults. Sports Medicine, 55(9), 2323-2338. Article 110723. https://doi.org/10.1007/s40279-025-02229-y
    • Van den Eynde, M. D. G., van der Bruggen, M. M., Houben, A. J. H. M., Reesink, K. D., Spronck, B., Delhaas, T., Scheijen, J. J. L. J. M., Miyata, T., & Schalkwijk, C. G. (2025). Pyridoxamine does not reduce arterial stiffness in an 8-week randomized double-blind placebo-controlled intervention trial with abdominally obese individuals. Diabetes Obesity & Metabolism, 27(9), 5332-5336. https://doi.org/10.1111/dom.16524
    • Steens, I. L. M., Schram, M. T., Houben, A. J. H. M., Berendschot, T. T. J. M., Koster, A., Bosma, H., Eussen, S. J. P. M., de Galan, B. E., & van Sloten, T. T. (2025). Type 2 diabetes and depression via microvascular dysfunction, neurodegeneration, inflammation, advanced glycation end products (AGEs), and arterial stiffness. Diabetes Obesity & Metabolism, 27(9), 4847-4858. Article 16527. https://doi.org/10.1111/dom.16527
    • Weerts, J., Schroen, B. L. M., Barandiaran Aizpurua, A., Berendschot, T. T. J. M., Brandts, L., Webers, C. A. B., Simons, S. O., Meex, S. J. R., Henry, R., van der Kallen, C. J. H., Brunner-La Rocca, H.-P., Knackstedt, C., Heymans, S. R. B., de Boer, R. A., van Empel, V. P. M., & Houben, A. J. H. M. (2025). Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study. Cardiovascular Diabetology, 24(1), Article 310. https://doi.org/10.1186/s12933-025-02850-1
    • Steens, I. L. M., Ji, Y., Sedaghat, S., Pankow, J., Klein, B. E. K., Cotch, M. F., Mcclelland, R. L., Hayden, K. M., Hughes, T. M., Bancks, M. P., Houben, A. J. H. M., Kroon, A. A., Koster, A., Bosma, H., Berendschot, T. T. J. M., de Galan, B. E., & van Sloten, T. T. (2025). Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population-based studies. Diabetes Obesity & Metabolism, 27(4), 2299-2304. Article 16217. https://doi.org/10.1111/dom.16217
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