Aaron Isaacs

Assistant Professor

Dr Aaron Isaacs completed his baccalaureate degree at the University of California, Berkeley in 1994. Afterwards, he spent several years working in the business and university administration sectors before entering the genetics field in a mouse genetics laboratory at Columbia University in New York City. In 2002, he moved to the Netherlands, where he embarked on his PhD studies in genetic epidemiology at Erasmus University Medical Center in Rotterdam. He completed and defended his thesis on the genetics of circulating lipid levels in 2007. His expertise in family- and population based genetic studies led to numerous collaborations with researchers on both the national and international levels, studying a broad array of phenotypes including lipid levels, blood pressure, anthropometric traits, ophthalmologic features and many others. Since 2008, he has focussed extensively on the genetics underlying cardiac electrophysiology. In 2015, Aaron moved to the Cardiovascular Research Institute Maastricht.

Currently, Aaron is working on a number of projects exploring the role of genomics and transcriptomics in a variety of outcomes, predominantly in the realm of cardiac electrophysiology and arrhythmias. These studies, in both population- and family-based settings, utilize large-scale “-omics” datasets, generated through the use of next generation sequencing (particularly RNA sequencing) and microarray technology, and a broad variety of analytical methods, including linkage, association, and bioinformatics approaches, to determine genes involved in disease pathology, progression, or relevant endophenotypes. The findings from these efforts give insight into disease etiology (and consequences); may identify useful targets for therapeutic intervention or biomarkers; and aid in risk stratification or molecular sub-typing of patients. Aaron closely collaborates with a number of CARIM Principal Investigators, conducting work in projects funded by (among others) the European Union and the Nederlandse Hartstichting (Dutch Heart Foundation) and participates in several large international genetics consortia.

Department of Physiology
Universiteitssingel 60, 6229 ER Maastricht
P.O. Box 616, 6200 MD Maastricht
Room number: M1.14
T: +31(0)43 388 18 62

  • 2020
    • Winters, J., von Braunmuhl, M. E., Zeemering, S., Gilbers, M., Ten Brink, T., Scaf, B., Guasch, E., Mont, L., Batlle, M., Sinner, M., Hatem, S., Mansour, M. K., Fabritz, L., Sommerfeld, L. C., Kirchhof, P., Isaacs, A., Stoll, M., Schotten, U., & Verheule, S. (2020). JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling. Scientific Reports, 10(1), [20074]. https://doi.org/10.1038/s41598-020-76932-3
    • Ntalla, I., Weng, L-C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., ... Munroe, P. B. (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11(1), [2542]. https://doi.org/10.1038/s41467-020-15706-x
    • Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., Hottenga, J-J., Arindrarto, W., Claringbould, A., van Iterson, M., Mei, H., Franke, L., Heijmans, B. T., 't Hoen, P. A. C., van Meurs, J., Brooks, A., Penninx, B. W. J. H., Boomsma, D., Isaacs, A., Pool, R., ... BIOS Consortium (2020). A characterization of cis- and trans-heritability of RNA-Seq-based gene expression. European Journal of Human Genetics, 28(2), 253-263. https://doi.org/10.1038/s41431-019-0511-5
    • Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A., & Isaacs, A. (2020). Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality. Diabetologia, 63(2), 253-260. https://doi.org/10.1007/s00125-019-05024-3
  • 2019
    • van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., Boomsma, D., Heijmans, B. T., t'Hoen, P. A. G., van Meurs, J., Isaacs, A., Jansen, R., Franke, L., ... BIOS Consortium (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
    • van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., ... Gieger, C. (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9, [11623]. https://doi.org/10.1038/s41598-019-47282-6
    • van Der Plaat, D., Vonk, J. M., Terzikhan, N., de Jong, K., de Vries, M., La Bastide-van Gemert, S., van Diemen, C. C., Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R. C. H., Postma, D. S., van Duijn, C. M., Boezen, H. M., Heijmans, B. T., Hoen, P. A. C. T., van Meurs, J., ... BIOS Consortium (2019). Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression. Human Molecular Genetics, 28(15), 2477-2485. https://doi.org/10.1093/hmg/ddz067
    • Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., ... BIOS Consortium (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, [3300]. https://doi.org/10.1038/s41467-019-10936-0
    • Liu, C-T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., ... Bouatia-Naji, N. (2019). Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals. Scientific Reports, 9(1), [9439]. https://doi.org/10.1038/s41598-019-45823-7
    • Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., ... van Duijn, C. M. (2019). An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis. Nature Communications, 10, [2581]. https://doi.org/10.1038/s41467-019-10487-4