CARIM Lecture Series
Overview CARIM lecture series 2010
June 18, 2010 from 12:00 hr to 13:00 hr
Location: Rode zaal/Coen Hemker zaal (UNS50 0.480)
Name invited speaker Dr. Daniel Sedding
University of Gießen
Lecture: "Role of Bone Marrow-derived vs. perivascular stem cells in atherosclerosis- and restenosis development"
Moderator: Dr. Judith Sluimer, Pathology
Dr. Sedding heads the Molecular Cardiology section of the Dept. of Cardiology and Angiology of the University of Gießen (http://www.ugmc.de/). He focuses on signal transduction and cell cycle regulation in smooth muscle- and endothelial cells that modulate vascular disease processes like atherosclerosis, restenosis and angiogenesis. His latest research topics include Sirt1 signaling, endothelial progenitor cells and CT imaging of angiogenesis.
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Date: Thursday June 17th, 2010 from 16.30 to 17.30 hr
Location: 3.142A Seminar Room Physiology
Prof. dr. Armin J. Reininger
University Clinic Munich (Germany)
Lecture:
New Insights in Thrombosis and Haemostasis: How Platelets and von Willebrand Factor Perform Better When Stressed
Moderator:
Johan Heemskerk
Dept. of Biochemistry, CARIM
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Speaker: Armin Reininger is professor and clinical at the Dept. of Transfusion Medicine and Haemostaseology at the Munich University Clinic. Being an excellent, quite motivating speaker, Armin Reininger is one of the international expert on flow-dependent processes leading to formation of a platelet thrombus and a clot. If you like to know how and why a stenotic site in the arterial vasculature is so risky for cardiovascular events, this is the chance …
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Thursday, June 3, 2010
12.30-13.30 hr
Location:
Library Radiology
4th floor – AZM (follow Secretariat Radiology)
Speaker: Prof. Dr. James A. Hamilton
Boston University School of Medicine
Lecture:
Non-invasive MRI discrimination of stable and vulnerable
atherosclerotic plaque in an animal model
Moderator: Jan Glatz, Dept. of Molecuar Genetics ( This e-mail address is being protected from spambots. You need JavaScript enabled to view it )
Jim Hamilton is Professor of Physiology and Biophysics and Director of the Center for Cardiovascular NMR and Imaging at Boston University Medical School. He is one of the leading scientists working on the development and application of new NMR and MRI methods for the characterization of lipids in intact atherosclerotic plaques and their correlation to plaque vulnerability to rupture.
Recent publication: Phinikaridou, Hamilton et al., Circ Cardiovasc Imaging 2010 (Epub March 1).
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June 1st, 2010 from 8:00 hr to 9:00 hr
Location: room 4.140A, Universiteitssingel 50
Speaker: Prof Barry Mc Grath
Monash University, Melbourne, Australia
Lecture:
What blood pressure targets should we aim at: Recent data on isolated clinic hypertension and hyperglycaemia
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Master Class
Monday, May 31st, 2010 from 12:30 hr to 13:30 hr
Location: room 4.140A, Universiteitssingel 50
Frederick Mahomed first explored using pulse contour analysis of peripheral arterial waveforms to obtain information about arterial stiffness. It is now 85 years since Bramwell and Hill demonstrated a significant correlation between aortic pulse wave velocity and age. However, it is only over the past 10 years that there has been a concerted effort to explore surrogate markers of arterial function. Rightly, many have viewed the evolution of this research with skepticism, awaiting convincing evidence of their utility as prognostic indicators. There are many indices that have been advanced, including those indicative of arterial stiffness in central or peripheral arterial segments (pulse wave velocity, stiffness index), indices of arterial compliance (systemic arterial compliance, distensibility) and a composite measure of wave reflection and systemic arterial stiffness (aortic augmentation index). These indices are not interchangeable, techniques used to determine any particular index are not always uniform and each is variously influenced by both physical and physiological factors. It is also important to recognize that there are dynamic or functional influences at play, such as endothelial-mediated changes, that can influence these indices and that the scope of these dynamic components has not been well characterized, except in the case of brachial artery flow-mediated vasodilatation.
So, what is the current status of arterial functional biomarkers? Do any of the arterial function indices provide more useful information than can be obtained by standard blood pressure measurements (including pulse pressure) and other risk factor analysis? Are they disturbed early in the pathophysiological process of arterial stiffness? Do they track appropriately with disease severity? Do they represent potential new therapeutic targets? Can a better understanding of the genetics and heritability of arterial function impact on disease prevention and/or lead to a more ‘personalized medicine’ approach to vascular disease? This workshop will address these issues.
Prof Barry McGrath is the Head of Vascular Medicine & Medicine at the Southern Clinical School, Monash University, and he is the Director of the Centre for Vascular Health at Monash University, Melbourne, Australia.
Moderator: Prof dr Harald Schmidt, Dept Pharmacology, This e-mail address is being protected from spambots. You need JavaScript enabled to view it
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March 24, 2010 from 12:00 hr to 13:00 hr
Location: UNS50 0480 (rode zaal/Coen Hemker)
Name invited speaker Dr. Dorien Schrijvers
University of Antwerp
Lecture:
(Auto-)Phagocytosis in Atherosclerosis: Implications for plaque stability
Moderator: Dr. Judith Sluimer, Pathology
Dr. Schrijvers has investigated the role of apoptosis, phagocytosis and autophagy in atherosclerosis. She is one of the pioneers who developed the concept of defective phagocytosis as a cause of apoptotic cell accumulation in advanced atherosclerosis.
In the lab of Dr. Ira Tabas she pharmacologically enhanced phagocytosis of apoptotic cells using a chemical chaperone. Currently she is focusing on autophagy in smooth muscle cells and macrophages in atherosclerosis
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Date January 27, 2010 from 16.00 hr to 17.00 hr
Location: Groene Zaal, UNS 50- 0.406
Name invited speaker Prof dr Steffen Massberg
University of Munich
Lecture:
“Platelets - multi-talented players in vascular remodeling and inflammation”
Moderator: Dr. Esther Lutgens, CARIM theme III, Pathology - This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Publications
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Massberg S, Konrad I, SchÃzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med. 2006 May 15; 203(5):1221-33. |
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Massberg S, von Andrian UH. Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. N Engl J Med. 2006 Sep 14; 355(11):1088-91. |
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Yano K, Gale D, Massberg S, Cheruvu PK, Monahan-Earley R, Morgan ES, Haig D, von Andrian UH, Dvorak AM, Aird WC. Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium. Blood. 2007 Jan 15; 109(2):613-5. |
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Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70. |
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Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1; 450(7166):110-4. |
Overview CARIM Lecture series 2009
Date Thursday October 8th, 2009 from 13:00 hr to 14:00 hr
Location: Groene Zaal, UNS 50- 0.406
Name invited speaker: John H. Griffin
The Scripps Research Institute, La Jolla, CA, USA
Lecture: Mutagenic Dissection of Activated Protein C’s Multiple Activities
Moderator: Tilman M. Hackeng, department Biochemistry
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Master Class (from 15:00-17:00) room 4.324A
Register with Dr. Gerry Nicolaes: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
“…..Administration of activated protein C (APC) reduces mortality in severe sepsis patients, provides neuroprotective activities in various murine brain injury models, and has multiple beneficial effects in a variety of animal injury models. APC exerts anticoagulant activities via inactivation of factors Va and VIIIa and cytoprotective activities via EPCR and PAR1. APC mutants with selectively altered and opposite activity profiles, i.e., greatly reduced anticoagulant activity or greatly reduced cytoprotective activities, have been designed and prepared using site-directed mutagenesis. Such APC mutants with distinctive activity profiles, namely cytoprotective-selective or antithrombotic selective activity profiles, have been used to delineate the relative importance of APC’s cell signaling activities versus its anticoagulant activity. Signaling selective APC mutants were as potent as wt-APC in reducing endotoxin-induced mortality and providing neuroprotection; studies implied that APC molecular species with potent antithrombotic activity but without robust cytoprotective activity are not sufficient to reduce mortality in endotoxemia. In summary, protein engineering can provide APC mutants that permit definitive in vivo mechanism of action studies for APC multiple activities, and such engineering may provide safer and more effective second generation APC mutants with reduced bleeding risk…. J.H.G.”
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Date: Wednesday February 11, 2009
Lecturer: Prof. Gordon Lowe, University of Glasgow, Scotland
Lecture: Can Blood Tests Predict Thrombosis?
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Master Class: Biomarkers for thrombosis in clinical studies
Prof. Gordon Lowe is Professor of Vascular Medicine in the University of Glasgow, Scotland; and Co-Director of the West of Scotland Haemophilia and Thrombosis Centre. His main research interest over the last 35 years has been the contribution of haemostatic and inflammatory biomarkers to cardiovascular disease.
Moderator: Prof. Dr. Hugo ten Cate, Dept of Internal Medicine/Biochemistry CARIM
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Date: July 9th 2009
Location: Groene Zaal UNS50 (0.406)
Name invited speaker: Mrs. Dr. Maren Roman
Virginia Polytechnic Institute and State University
Lecture: Cellulose nanocrystals – A novel drug delivery system
Dr. Maren Roman is developing a new type of fluorescent nanocrystals for applications in biomedical imaging and drug delivery. In contrast to the well-known quantum dots, the crystals contain exclusively non-toxic materials, while having similar fluorescence yields. Supposedly they will allow future clinical applications and current research is in that direction.
Moderator: Prof. Dr. Marc A.M.J. van Zandvoort, Department of BioMedical Engineering, CARIM.
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Overview CARIM Lecture series 2008
Date: 10-04-2008
Lecturer: Dr M-L Bochaton-Piallat, University of Geneva, Switzerland
Title: S100A4, a marker of activated smooth muscle cells in atherosclerosis and restenosis
Moderator: Dr G. van Eys, Molecular Genetics,
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Date: 08-05-2008
Lecturer: Prof Dr J. Baynes University of South Carolina, USA
Title: Non-Enzymatic Chemistry of Aging and Vascular Disease
The lecture will be followed by a master class chaired by Profs John Baynes and Susan Thorpe in which selected PhD students will present their research
Moderator: Dr Casper Schalkwijk, Internal Medicine
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Date: 27-05-2008
Lecturer: Prof Dr J. Kuiper Leiden Amsterdam Center for Drug Research, The Netherlands
Title: Immunomodulation of the atherosclerotic response
The lecture will be followed by a master class chaired by Prof Kuiper in which selected PhD students will present their research
Moderator: Dr Esther Lutgens, Pathology
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Date: 04-06-2008
Lecturer: Marc Tjwa, Assistant Professor, Leibniz AG, Center for Molecular Medicine,
Institute of Cardiovascular Regeneration, University of Frankfurt, Germany
Title: Role of uPAR and plasmin in bone marrow progenitor cell retention and mobilization
Moderator: Dr Esther Lutgens, Pathology
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Date: 28-09-2008
Lecturer: Dr. A. Wiethoff
University: King’s College, London, United Kingdom
Lecture:Fibrin: A Target for Molecular Imaging
Master Class: Translational Molecular Imaging: opportunities and pitfalls
Moderator: Dr. ME Kooi, department Radiology, CARIM theme III. This e-mail address is being protected from spambots. You need JavaScript enabled to view it
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