Radical Medicine: NO-cGMP and reactive oxygen species in vascular disease and personalized medicine

Oxidative stress, an excess of radical and other reactive oxygen species (ROS), has been suggested as a major disease mechanism. However, the major clinical trials using anti-oxidants have been failures, even suggesting serious side effects. Our lab pursues completely different approaches: first, instead of letting radicals form and then scavenge them we will identify their disease-relevant sources and prevent their formation or specifically repair the damage caused by ROS. Second, we will differentiate beneficial signalling roles of ROS. In combination, this will result in unprecedented precision and molecular specificity. [more]