research
programs
Metabolic syndrome and microvascular dysfunction
A major aim of the program is to deliver specific and sensitive diagnostic biomarkers for the identification of patients developing insulin resistance and type 2 diabetes and to identify patients with high risk of micro- and macrovascular complications. A second aim of our program is to obtain insight in the pathophysiology of vascular complications in patients with the metabolic syndrome and diabetes at the molecular level. [more]
Participants
HEAD OF PROGRAM
Coen StehouwerACADEMIC STAFF
PhD STUDENTS
TECHNICAL STAFF
Related publications
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published on 14-09-2010
Arterial calcifications -
published on 23-07-2010
Inhibition of thrombin formation by active site mutated (S360A) activated protein C -
published on 01-09-2010
Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability as determined by thrombin generation in plasma: the role of central obesity and low-grade inflammation. The Hoorn Study -
published on 01-12-2010
Body composition as determinant of thrombin generation in plasma: the Hoorn study -
published on 01-12-2010
Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus -
published on 01-08-2010
Angiotensin II enhances insulin-stimulated whole-body glucose disposal but impairs insulin-induced capillary recruitment in healthy volunteers -
published on 01-10-2010
Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity-but not a PCOS-associated phenomenon -
published on 01-04-2010
Distinct ethnic differences in lipid profiles across glucose categories -
published on 01-05-2010
Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress -
published on 01-05-2010
Irbesartan treatment does not influence plasma levels of the advanced glycation end products CML and CEL in patients with type 2 diabetes and microalbuminuria. An IRMA2 substudy -
published on 01-09-2010
Urinary D-lactate levels are increased in type 2 diabetic patients and are inversely associated with ankle arm index: The CODAM study -
published on 01-08-2010
Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: a randomised crossover trial -
published on 01-09-2010
The inverse association between alcohol intake and complement C3 can be attributed to wine consumption and is explained by inflammation, HDL and insulin resistance, the CODAM study -
published on 01-09-2010
Diabetes, prediabetes and cancer mortality -
published on 01-01-2010
Lifetime vigorous but not light-to-moderate habitual physical activity impacts favorably on carotid stiffness in young adults: the amsterdam growth and health longitudinal study -
published on 01-06-2010
Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure -
published on 01-06-2010
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion -
published on 01-08-2010
Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study -
published on 01-10-2010
Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values' -
published on 20-05-2010
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial -
published on 09-01-2010
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Emerging Risk Factors Collaboration. -
published on 26-06-2010
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies -
published on 01-03-2011
Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes -
published on 05-08-2011
Abdominal Fat Mass Is Associated With Adaptive Immune Activation: The CODAM Study -
published on 05-09-2011
Irbesartan treatment does not influence plasma levels of the advanced glycation end products N{varepsilon}(1-carboxymethyl)lysine and N{varepsilon}(1-carboxyethyl)lysine in patients with type 2 diabetes and microalbuminuria. A randomized controlled trial -
published on 05-09-2011
Immune complexes in acute adult-onset Henoch-Schonlein nephritis -
published on 05-09-2011
The association between the metabolic syndrome and peripheral, but not coronary, artery disease is partly mediated by endothelial dysfunction: the CODAM study -
published on 05-09-2011
The cross-sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study) -
published on 05-09-2011
Neutrophils and T cells: Bidirectional effects and functional interferences
